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T h e e m b r y geenuine n i c f i s s u r e e x t e n d sf r o m t h e r i m o geenuine t h genunie c u p n e a r t h e l e n s t o t h e d i s t a l o p t i c stalk. de Bustros S.

In volunteers with severe (CLcr lt;30 mLmin) renal impairment, sildenafil clearance was reduced, resulting in approximately doubling of AUC and C max compared to age-matched volunteers with no renal impairment [ see Dosage and Administration (2. 5), and Use in Specific Populations (8. 6) ]. In addition, N-desmethyl metabolite AUC and C max values significantly increased by 200 and 79, respectively in subjects with severe renal impairment compared to subjects with normal renal function. Hepatic Impairment: In volunteers with hepatic impairment (Child-Pugh Class A and B), sildenafil clearance was reduced, resulting in increases in AUC (85) and C max (47) compared to age-matched volunteers with no hepatic impairment. The pharmacokinetics of sildenafil in patients with severely impaired hepatic function (Child-Pugh Class C) have not been studied [ see Dosage and Administration (2.

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